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The movie begins with Dr. Carl Stoner (Martin) selling a mysterious creature in a crate to a carnival owner. It is later discovered that the creature is actually part-man/part-snake, the result of one of Stoner's bizarre experiments. College student David Blake (Benedict) is hired as an assistant by Stoner, an ophiologist. It transpires that Stoner's previous assistant had mysteriously left town without telling anyone (Stoner explains that he had gone back home to attend to a sick relative).
Unbeknownst to David or anyone else, Stoner is a delusional man, convinced that humanity is doomed and is attempting to prepare for what he believes to be the inevitable by working out a method of transforming humans into reptiles that can survive pollution and any other ecological disaster that would wipe humanity out...
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